Side Effects:

Common Abdominal pain, Constipation, Diarrhoea, Epigastric pain, Flatulence, Nausea, Vomiting, Indigestion.

Expert advice for Dolonex Injection
Inform your doctor if you have ever been diagnosed with kidney or liver problems. It should be taken with food or milk to avoid getting an upset stomach. It can cause serious complications like stomach bleeding and kidney problems if taken for a long time. Dolonex can raise your risk of blood clots, heart attack, or a stroke. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Frequently Asked Questions

Q. What is the difference between Dolonex and diclofenac?
Both Dolonex and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Dolonex.

Q. What is the difference between Dolonex and naproxen?
Both Dolonex and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Dolonex.

Q. What is the difference between Dolonex and meloxicam?
Both Dolonex and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Dolonex.

Q. What is the difference between Dolonex and ketoprofen?
Both Dolonex and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Dolonex. Ketoprofen gel also showed excellent tolerability.

Q. What is the difference between Dolonex and tramadol?
Dolonex is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

Q. What is the difference between Dolonex and nimesulide?
Both Dolonex and nimesulide are pain killers. However, Dolonex is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Q. Can Dolonex be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Dolonex or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Dolonex.

Q. Are Dolonex and aspirin same?
No. Dolonex and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Q. Can Dolonex be used along with dexamethasone?
No. Dolonex should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Q. Can Dolonex be used with methocarbamol?
Yes. Methocarbamol can be used with Dolonex as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Can Dolonex be used along with paracetamol?
Yes. Paracetamol can be used with Dolonex as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Is Dolonex a NSAID?
Yes. Dolonex is a non-steroidal anti-inflammatory drug (NSAID).

Q. Is Dolonex a sulfa drug?
Dolonex is a sulphur containing compound. Dolonex can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Q. Is Dolonex a blood thinner?
No. Dolonex is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Q. Is Dolonex a muscle relaxant?
No. Dolonex is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Q. Is Dolonex a narcotic?
No. Dolonex is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Q. Can Dolonex be used in hypertension?
No. Dolonex is not a medication to control hypertension. It is important to note that Dolonex decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Dolonex.

Q. Can Dolonex be used along with Losartan?
No. Dolonex should not be combined with Losartan. It is important to note that Dolonex decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dolonex.

Q. Can Dolonex be used with Lisinopril?
No. Dolonex should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dolonex.

Q. Can Dolonex be used with calcium channel blocker?
Yes. Dolonex can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Q. Can Dolonex be used with Tizanidine?
Yes, Dolonex can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Q. Why is beta cyclodextrin added to Dolonex?
Yes. Dolonex can be combined with beta-cyclodextrin. Research has shown that combining Dolonex with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Q. Are there any alternatives of Dolonex?
Yes. There are alternatives to Dolonex. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Q. What are the contraindications for Dolonex?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Q. Can Dolonex be used in the treatment of allergy?
No. Dolonex is not a drug to treat allergy. It is a pain killer.

Q. How long does Dolonex work?
Dolonex is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Q. Can you get high by using Dolonex?
No. Dolonex is not known to cause high. It is a non-narcotic painkiller.

Q. Can Dolonex be used to treat menstrual cramp?
Dolonex is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Q. Can I use Dolonex for a migraine?
Dolonex is not approved for the treatment of migraine. Research studies have shown that Dolonex is effective in significantly decreasing the pain associated with migraine without aura.

Q. Is Dolonex effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Dolonex as the cause of back pain can be different for different person.

Q. Is Dolonex affective in gout management?
Yes. Dolonex can be given for the treatment of acute gout. Research studies have shown Dolonex to be highly effective in the treatment of acute gout.

Q. Can you donate blood when on the medication with Dolonex?
Yes. You can donate blood when on Dolonex. Do inform your doctor before donating blood.

Q. Can I use Dolonex if I am a diabetic?
Dolonex in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Dolonex so taking piroxicam can lead to increased risk of renal failure by many folds.

Q. Can I use Dolonex if I have a deranged renal function?
No. Dolonex should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Q. Can Dolonex lead to skin reactions?
Yes. Dolonex is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Q. Can I use Dolonex if I am pregnant?
No. Dolonex should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Q. Can I use Dolonex if I have peptic ulcer disease?
No. Dolonex is contraindicated in cases of active peptic ulcer disease. Dolonex is known to cause gastric ulceration and bleeding.

Q. Can I use Dolonex if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Q. Can Dolonex lead to difficulty in conception?
Yes. Dolonex can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Q. Can Dolonex be used with diuretics?
No. Dolonex should not be used with diuretics. Dolonex reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Q. Can Dolonex be used with lithium?
No. Dolonex should not be used with lithium. Dolonex leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Q. Can Dolonex be used with warfarin?
No. Dolonex should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Q. What increases the chances of getting a gastric ulcer when I am already taking Dolonex?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Dolonex?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Q. What are the serious side effects of Dolonex?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.